My Site Title

My Site Tagline

PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8þ T-cell Function

publication date: Jan 22, 2019
View a Printer Friendly version of this page, allowing you to print the page. Send a summary of this page to someone via email.

Although checkpoint inhibitors that block CTLA-4 and PD-1 have improved cancer immunotherapies, targeting additional checkpoint receptors may be required to broaden patient response to immunotherapy. PVRIG is a coinhibitory receptor of the DNAM/TIGIT/CD96 nectin family that binds to PVRL2. We report that antagonism of PVRIG and TIGIT, but not CD96, increased CD8þ T-cell cytokine production and cytotoxic activity. The inhibitory effect of PVRL2 was mediated by PVRIG and not TIGIT, demonstrating that the PVRIGPVRL2 pathway is a nonredundant signaling node.



Sorry this area of the site is available to contributors and subscribers only.
If you're not yet a subscriber why not join today?

If you are already a subscriber, please login.

If you believe you should be able to view this area then please contact us and we will try to rectify this issue as soon as possible.


To gain access to the members only content click here to subscribe.

You will be given immediate access to premium content on the site.